Milestone 1

This milestone is designed to help you build the foundation of your final project. You will choose a well-known individual from history or current popular literature with a known physiological disease or illness. You must submit your subject and topic of interest to your instructor for approval. You will introduce the individual’s background (including time and location), identify the pathophysiology for the selected disease or illness, and explain the clinical manifestations of multiple body systems for the case.

Stephen Hawking will be the selected case. The disease he had was ALS. 

Prompt

Identify your selected case, describing how the normal physiology is changed by the disease state. In addition, define pathophysiology, the clinical manifestations (that is, signs and symptoms), and how each of these can be explained by alteration in physiology.

Discuss the extent to which the clinical manifestations in the selected case affect multiple body systems. Include a historical analysis that describes the pathophysiology for the selected disease or illness. Propose historical explanations for variations in findings (when applicable) and include evidence-based resources to frame your discussion of adaptation and stressors for system analysis.

Specifically for Milestone One, the following critical elements must be addressed:

Introduce your selected case

Identify the individual you selected and the illness and provide a brief explanation of why you selected this case.

Describe how normal physiology is changed by the disease state for your selected case.

Define the pathophysiology and general clinical manifestations associated with your selected case and how they may be explained by altered physiology. Be sure to support your claims with scholarly evidence.

Assess the extent to which clinical manifestations of your selected case affect multiple body systems, using scholarly evidence to support your claims.

1. History of selected case

Describe historical variations (that is, examples of individuals with the selected disease or illness) of your selected case, using evidence from literature.

Identify physiological stressors that may affect the course of the disease or illness and explain their impact.

1. Identify adaptive physiological mechanisms that may affect the course of the disease for your selected case.

Assess the historical impact of patient care technologies on patient outcomes for your selected case. Be sure to justify your claims with scholarly evidence.